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KMID : 0357419960260020269
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Korean journal of Virology
1996 Volume.26 No. 2 p.269 ~ p.272
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Effect of Caffeine on Transformation Induced by Adenovirus type 12
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Abstract
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Adenovirus group consists of over 100 related viruses which have been isolated from respiratory or gastro-intestinal tract of primate, cattle, dog and mice. Approximately 40 serologic types of adenovirus producing a variety of human respiratory
and
conjunctival infection were identified. Adenoviruses are icosahedral virions containing double-stranded linea DNA. They are 70nm to 90nm in diameter and each of capsid is composed of 252 capsomeres. Several numbers of this group, including types
commonly associated with respiratory disease in man, are capable of producing malignant tumors in young hamsters and a few types have been shown to be oncogenic in young rat. Previous report involving effect of Hormone on replication of
adenovirus(9)
has been carried out. The present report represents a continuation of previous study. To obtain evidence concerning the effect of caffeine on the transformation, investigation of adenovirus type 12 of this group was undertaken. For practical
consideration it was desirable to investigation of the effect of caffeine on the adenovirus type 12-induced transformation in L cell. Results were as follows;
1. Adenovirus type 12-induced transformation was inhibited in the presence of caffeine.
2. Yields of adenovirus type 12 in L cell were slightly inhibited by treatment of caffeine.
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